Memory, generalization, and the neural code.
The brain can store a lifetime of detailed memories while simultaneously creating abstract, generalized categories to quickly classify stimuli and experiences. How the brain implements these two conflicting processes to achieve flexible behavior and high memory capacity is still an open question.
In my research, I interrogate neural data using tools and ideas from machine learning and statistical physics to tackle this problem from a computational standpoint, investigating the geometrical coding properties of neural representations and their implications on cognition and memory.
As a physicist by training, I believe the finest scientific progress happens when experiments and theory guide each other. For this reason, my approach is strongly data-oriented, in closed-loop collaboration with experimental neuroscientists. Ongoing and recent collaborations include the Siegelbaum, Salzman, Kellendonk, and Hussaini Labs (Columbia), Schmidt-Hieber Lab (Institut Pasteur), Lopez-Roja Lab (UWM), and Rutishauser Lab (Caltech & Cedars-Sinai).
I received my Ph.D. in Statistical Physics from École Normale Superieure in Paris, under the supervision of Rémi Monasson and Simona Cocco. Currently, I am a postdoc in the group of Stefano Fusi in the Center for Theoretical Neuroscience of the Zuckerman Institute at Columbia University in New York.
Selected Works
Publications and Preprints
The representational geometry of emotional states in basolateral amygdala
P O'Neil*, L Posani*, J Meszaros, P Warren, C.E. Schoonover, A. Fink, S Fusi, C.D. Salzman
BioRxiv, 2023
Tuned geometries of hippocampal representations meet the computational demands of social memory
L Boyle*, L Posani*, S Irfan, SA Siegelbaum, S Fusi
Neuron, 2024
L Posani, F Rizzato, R Monasson, S Cocco
PLOS Comp Bio, 2023
Minimal epistatic networks from integrated sequence and mutational protein data.
S Cocco, L Posani, R Monasson
BioRxiv, 2023
Adolescent thalamic inhibition leads to long-lasting impairments in prefrontal cortex function
L Benoit, E Holt, L Posani, S Fusi, A Harris, S Canetta, C Kellendonk
Nature Neuroscience, 2022
R Ocadiz-Gomez, M Trippa, L Posani, R Monasson, S Cocco, C Schmidt-Hieber
Nature Communications, 2022
Integration and multiplexing of positional and contextual information by the hippocampal network
L Posani, S Cocco, R Monasson
PLOS Comp Bio, 2018
M Allegra, L Posani, R Ocasio-Gomez, C Schmidt-Hieber
Neuron, 2020
Functional connectivity models for decoding of spatial representations from CA1 recordings
L Posani, S Cocco, K Jezek, and R Monasson
J Comp Neur, 2017
Statistical physics and representations in real and artificial neural networks
S Cocco, R Monasson, L Posani, S Rosay, and J Tubiana
Physica A: Statistical Mechanics, 2017
Functional networks from inverse modeling of neural population activity
S Cocco, R Monasson, L Posani, and G Tavoni
Current Opinion in Systems Biology, 2017
Greetings, fellow human!
If you would like to work together, whether you are an experimentalist or a theoretician (or beyond these antiquated binary standards), I’ll be happy to have a (virtual or real) chat in front of a (virtual or real) coffee.