Hi, I am Lorenzo 👋 I am a new principal investigator at the Paris Brain Institute and CNRS. I am broadly interested in how the structural and functional properties of the neural code support cognitive computation, a question I approach through data analysis, simulations, and mathematical modeling.
I received my Ph.D. in Statistical Physics from École Normale Supérieure and worked as a postdoctoral scientist at the Institut Pasteur and the Center for Theoretical Neuroscience at Columbia University.
My recent work focuses on how the geometry of neural representations provides a computational substrate for cognitive processes such as memory and abstraction (see, e.g., my work on social memory in the hippocampus and emotional states in the amygdala) and how single-neuron properties influence population coding and vice versa (see my work on the neural code along the cortical hierarchy).
Before that, I mainly worked on continuous attractor networks and statistical inference models applied to neural data, specifically to investigate how memorized cognitive maps are retrieved from sensory cues and how similar environments are pattern-separated in the hippocampus.
If you are interested in working with me, get in touch for opportunities on all levels at the Paris Brain Institute, including master’s internships, research assistant, PhD thesis (Sorbonne graduate program), and Postdoc.
(all kinds of brains!)
Selected Works
See my CV or Google Scholar for the full publications list
Rarely categorical, always high-dimensional: how the neural code changes along the cortical hierarchy
L Posani*, S Wang*, S Muscinelli, L Paninski, S Fusi
bioRxiv (2024): 2024-11
Press: The Transmitter
Tuned geometries of hippocampal representations meet the computational demands of social memory
L Boyle*, L Posani*, S Irfan, SA Siegelbaum, S Fusi
Neuron 112, no. 8 (2024) - on the cover! ☝️
Integration and multiplexing of positional and contextual information by the hippocampal network
L Posani, S Cocco, R Monasson
PLOS Computational Biology 14, no. 8 (2018)
Software & Resources
See also my Resources page
Decodanda is a Python package designed to expose a user-friendly and flexible interface for population activity decoding, avoiding the most common pitfalls through a series of built-in best practices.
Colab Notebook: Neural Geometry
Material for the 2024 course on the Geometry of Neural Representations (part of Columbia’s graduate course in Advanced Topics in Theoretical Neuroscience)
Colab Notebook: The Art of Decoding Neural Representations
Material for the 2022 course on Neural Decoding (part of Columbia’s graduate course in Advanced Topics in Theoretical Neuroscience):